Recurrent Pregnancy Loss (RPL): An overview

Author(s): Shehnaz Sultana, Pratibha Nallari, Venkateshwari Ananthapur

Recurrent pregnancy loss (RPL) is defined as two or more pregnancies losses occurring before 20 weeks of gestation and affecting 1-3% of the couples. Chromosomal abnormalities, uterine defects, thrombophilia, immunological factors, endocrine and metabolic factors are the known risk factors involved in the causation of recurrent pregnancy loss in 50% of the cases. However, remaining 50% of the recurrent pregnancy loss cases are unexplained. A lot of research is going on in the area of recurrent pregnancy loss globally and the results are inconsistent due to study designs, sample size, ethnicity etc. The present review took an insight into the overall risk factors involved in the causation of explained recurrent pregnancy loss to help the researchers to identify the origin of pregnancy loss and to provide best investigation and treatment strategy for women with recurrent pregnancy loss.

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